James Brown
Papers
1
Total Citations
131
H-Index
1
About
James Brown is a leading figure in structural biology, whose work has revolutionized protein crystallization through high-throughput automation. His key research centers on developing and validating nanolitre-scale crystallization technologies, dramatically reducing the sample volumes and time required for structural studies. Brown’s most influential contribution, detailed in his highly cited 2003 paper (131 citations), presents the first systematic results from a robotic system that sets up 100-nanoliter vapour-diffusion sitting-drop experiments. By surveying a database of over 50 unrelated protein samples, he demonstrated the practical, day-to-day reliability of this miniaturized approach, proving that nanolitre crystallization could yield high-quality crystals for diverse targets. This work laid the foundation for modern structural genomics pipelines, enabling the rapid screening of thousands of conditions with minimal protein consumption. Brown’s achievements have accelerated the pace of drug discovery and fundamental biology, making him a pioneer in transforming crystallization from an art into a robust, scalable science. His legacy continues to inspire researchers seeking efficient methods for determining protein structures.
Research Focus
Key Achievements
Top Papers
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