C.E. Nichols
Papers
1
Total Citations
131
H-Index
1
About
C.E. Nichols has made significant contributions to structural biology, particularly in the development and application of high-throughput protein crystallization methods. Their most-cited work, a 2003 study on nanolitre-scale crystallization experiments, introduced a robotic system for setting up 100 nl-scale vapour-diffusion sitting-drop trials, achieving over 130 citations. This research provided a critical snapshot of crystallization outcomes across more than 50 unrelated protein samples, demonstrating the practical utility of miniaturized, automated approaches in structural genomics. By streamlining the crystallization pipeline, Nichols enabled faster, more efficient screening of challenging targets, reducing sample consumption and accelerating structure determination. Their work has directly influenced modern high-throughput crystallography, supporting large-scale projects and drug discovery efforts. Nichols’ contributions exemplify how methodological innovation can transform experimental workflows, making them a key figure in advancing structural biology’s capacity to tackle complex biological questions.
Research Focus
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Top Papers
- 1