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About

Raquel Manso-Sancho is a structural biologist whose work has significantly advanced the field of protein crystallography through the development and application of high-throughput crystallization technologies. Her research focuses on optimizing experimental pipelines to accelerate the determination of macromolecular structures, a critical step in understanding biological function and drug design. Her most notable contribution, the highly cited 2003 paper "A procedure for setting up high-throughput nanolitre crystallization experiments. II. Crystallization results," with over 130 citations, provides a seminal analysis of results from a robotic system performing 100-nanoliter-scale vapor-diffusion sitting-drop experiments. By surveying a database of over 50 unrelated protein samples, this work demonstrated the practical viability and efficiency of miniaturized crystallization trials, offering a crucial snapshot of real-world project outcomes. This achievement helped establish nanolitre-scale robotics as a standard tool in structural biology, reducing sample consumption and enabling the screening of challenging targets. Manso-Sancho’s contributions have thus been instrumental in streamlining the path from gene to structure, empowering researchers to tackle larger and more complex biological systems.