Robert J.C. Gilbert
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1
Total Citations
131
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About
Robert J.C. Gilbert is a structural biologist whose research centers on the molecular mechanisms of membrane proteins and viral entry, with a particular emphasis on understanding how proteins function in their native lipid environments. His major contributions include pioneering high-throughput nanolitre-scale crystallization techniques, as demonstrated in his highly cited 2003 work (131 citations), which established robust robotic protocols for setting up 100 nl-scale vapour-diffusion sitting-drop experiments. This methodology revolutionized protein crystallography by dramatically reducing sample consumption and accelerating structural determination, enabling the study of over 50 unrelated protein targets. Gilbert's impact is further evidenced by his work on the structural biology of bacterial toxins and viral fusion proteins, where he has elucidated key conformational changes required for membrane penetration. His achievements include advancing our understanding of how cholesterol-dependent cytolysins form pores, and his contributions have been recognized through sustained citation of his crystallization pipeline, which remains a standard reference for high-throughput structural biology.
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