A.R. Aricescu
Papers
2
Total Citations
190
H-Index
2
About
Dr. A.R. Aricescu is a leading structural biologist whose work has revolutionized the high-throughput production and crystallization of challenging mammalian proteins. His key research areas include membrane protein structural biology, receptor signaling, and the development of automated platforms for protein expression and crystallization. Dr. Aricescu’s major contributions lie in bridging the gap between traditional, labor-intensive biochemical methods and modern, scalable structural genomics pipelines. His highly cited 2003 paper (131 citations) established a robust, robotic system for nanolitre-scale crystallization trials, demonstrating that miniaturization could yield high-quality crystals across a diverse array of protein targets. Equally transformative, his 2011 work (59 citations) pioneered the automation of large-scale transient protein expression in mammalian cells, overcoming the bottleneck of stable cell line generation. This innovation enabled the rapid, cost-effective production of complex eukaryotic proteins for structural studies. By systematically removing technical barriers, Dr. Aricescu has empowered the structural biology community to tackle previously intractable targets, making him a pivotal figure in modern integrative structural biology.
Research Focus
Key Achievements
Top Papers
- 1
- 2Automation of large scale transient protein expression in mammalian cells59 citations · 2011