Mark C. Sleeman
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1
Total Citations
131
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About
Mark C. Sleeman is a leading figure in structural biology, whose work has revolutionized high-throughput protein crystallization. His key research areas encompass the development of automated, miniaturized crystallization technologies and their application to challenging biological targets. Sleeman’s major contribution lies in demonstrating the practical viability of nanolitre-scale crystallization, proving that robotic systems could reliably produce diffraction-quality crystals from just 100 nanolitres of protein solution. His landmark 2003 paper, cited over 130 times, provided the first comprehensive survey of results from this approach, analyzing over 50 diverse protein samples to show that the method dramatically reduces sample consumption while accelerating the discovery of crystallization conditions. This work fundamentally changed how structural genomics projects and academic laboratories approach crystallogenesis, enabling the high-throughput pipelines that underpin modern structural biology. Sleeman’s achievements include establishing the operational protocols that made nanolitre crystallization a routine, robust technique, directly enabling the determination of countless protein structures and advancing drug discovery efforts worldwide.
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