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About

T. Krojer is a structural biologist and chemical biology researcher whose work sits at the intersection of X-ray crystallography, fragment-based drug discovery, and high-throughput experimental methodology. Krojer has made significant contributions to streamlining the pipeline from crystal preparation to ligand identification, most notably through pioneering the use of acoustic dispensing technology for crystal soaking. This innovation, described in a widely cited 2017 paper with 119 citations, addressed a critical bottleneck in structural biology workflows by enabling gentle, fast, and reproducible compound delivery to protein crystals at scale. Building on this foundation, Krojer has advanced the field of fragment hit progression — historically one of the most challenging phases of early drug discovery — through the development of Binding-Site Purification of Actives (B-SPA), a methodology that couples multi-step array synthesis with high-throughput crystallography to efficiently convert weakly binding fragment hits into more potent leads. This work, published across multiple iterations between 2023 and 2025, reflects a sustained commitment to making structure-guided drug discovery more practical and scalable. Krojer's research is particularly valuable for students and researchers seeking to integrate crystallographic methods with medicinal chemistry workflows in an accessible and cost-effective manner.