A. Douangamath

Papers

Total Citations

123

H-Index

About

A. Douangamath is a leading structural biologist whose work has revolutionized the high-throughput preparation of protein crystals for X-ray diffraction, a critical step in drug discovery. Their key research focuses on developing innovative methods to overcome bottlenecks in crystallography, particularly in ligand-binding studies. Douangamath’s major contribution is the development of a groundbreaking technique using acoustic droplet ejection for crystal soaking, as detailed in their most-cited paper, "Gentle, fast and effective crystal soaking by acoustic dispensing" (2017, 119 citations). This method dramatically accelerates and streamlines the process of introducing small molecules into protein crystals, enabling faster and more efficient data collection at modern synchrotron beamlines. By addressing the upstream bottleneck in sample preparation, their work has directly enhanced the capacity for high-throughput structural studies, a cornerstone of modern rational drug design. This achievement has made them a pivotal figure in the field, with their techniques widely adopted to leverage the increasing speed and brightness of X-ray sources.