Jia Tsing Ng

Papers

Total Citations

123

H-Index

About

Jia Tsing Ng is a structural biologist whose work has significantly advanced high-throughput crystallography, particularly in the study of protein-ligand interactions. Her primary research focuses on developing innovative methods to overcome bottlenecks in X-ray diffraction experiments, specifically in sample preparation for drug discovery. Ng’s most notable contribution is the development of a groundbreaking technique for crystal soaking using acoustic droplet ejection, detailed in her highly cited 2017 paper (119 citations). This method enables gentle, fast, and effective introduction of ligands into protein crystals, dramatically accelerating the pace of structural studies. By leveraging acoustic dispensing, Ng’s approach reduces sample handling and improves reproducibility, effectively pushing the frontier of high-throughput data collection. This work directly addresses the growing gap between rapid beamline capabilities and slower upstream sample preparation. Her achievements have been recognized as a key enabler for modern fragment-based drug design and structural genomics, making her a leading figure in the optimization of crystallographic workflows. Ng’s research continues to shape how researchers prepare crystals for the increasingly powerful synchrotron and XFEL light sources.