Harold Grosjean
Papers
3
Total Citations
16
H-Index
3
About
Harold Grosjean is pioneering a transformative approach to fragment-based drug discovery, with a focus on overcoming the critical bottleneck of hit progression. His research centers on developing high-throughput crystallography and innovative synthetic methodologies to efficiently advance weak fragment hits into potent lead compounds. Grosjean’s major contribution is the invention of Binding-Site Purification of Actives (B-SPA), a technique that combines multi-step array synthesis with high-throughput crystallography to enable large-scale, rapid progression of fragment hits. This work, detailed in his most-cited 2025 paper (9 citations), addresses a long-standing challenge in the field, where traditional methods struggle to efficiently grow fragments. His 2023 paper (4 citations) further demonstrates the power of low-cost robotics and crude reaction mixture deconvolution for rapid structural data collection. Collectively, his research has garnered over 16 citations, establishing him as a rising leader in structural biology and medicinal chemistry. By making fragment progression faster, cheaper, and more scalable, Grosjean’s work promises to unlock the full potential of fragment-based approaches for discovering new therapeutics.
Research Focus
Key Achievements
Top Papers
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