L. Koekemoer
Papers
3
Total Citations
16
H-Index
3
About
L. Koekemoer is a pioneering researcher in fragment-based ligand discovery, specializing in the development of innovative methodologies that bridge the gap between initial fragment screening and hit progression. Their key research areas include high-throughput crystallography, array synthesis, and binding-site purification techniques. Koekemoer’s major contribution is the development of Binding‐Site Purification of Actives (B‐SPA), a groundbreaking approach that combines multi-step array synthesis with high-throughput crystallography to efficiently progress fragment hits to potency—a long-standing challenge in the field. Their work has been recognized through notable publications, including a 2025 paper with 9 citations that outlines the transformative potential of B-SPA, and a 2023 study demonstrating low-cost robotics for rapid fragment growth from crude arrays. With a total of 16 citations across their most-cited works, Koekemoer’s research is reshaping how scientists approach fragment hit progression, offering scalable, cost-effective solutions that promise to unlock the full potential of fragment-based drug discovery. Their achievements highlight a commitment to addressing underserved areas in methodology, making them a key figure in advancing target-based ligand discovery.
Research Focus
Key Achievements
Top Papers
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