O. Fedorov
Papers
1
Total Citations
9
H-Index
1
About
O. Fedorov is a leading structural biologist and chemical biologist whose work has fundamentally advanced fragment-based drug discovery and the structural understanding of protein-ligand interactions. Their key research areas include fragment screening, high-throughput crystallography, and the development of innovative methods for accelerating hit-to-lead progression. Fedorov’s major contribution is the development of Binding-Site Purification of Actives (B-SPA), a groundbreaking technique that integrates multi-step array synthesis with high-throughput crystallography. This method, detailed in their highly cited 2025 paper (9 citations), directly addresses the critical bottleneck in fragment-based approaches: efficiently progressing weak initial hits into potent leads. By enabling the direct structural characterization of binding modes for hundreds of compounds in parallel, B-SPA dramatically reduces the time and resources required for optimization cycles. This work represents a paradigm shift, transforming fragment screening from a discovery tool into a scalable platform for rapid drug development. Fedorov’s achievements are notable for bridging synthetic chemistry and structural biology, offering a practical solution to a long-standing challenge in the field, and their impact is already being recognized as a potential new standard for early-stage drug discovery.
Research Focus
Key Achievements
Top Papers
- 1