Storm Hassell‐Hart
Papers
3
Total Citations
16
H-Index
3
About
Storm Hassell-Hart is a leading researcher in fragment-based ligand discovery, specializing in the critical bottleneck of progressing weak fragment hits to potent leads. Their key research areas include high-throughput crystallography, array synthesis, and innovative purification techniques for drug discovery. Hassell-Hart's major contribution is the development of Binding-Site Purification of Actives (B-SPA), a groundbreaking methodology that combines multi-step array synthesis with high-throughput crystallography to enable efficient, large-scale fragment hit progression. This work addresses a long-standing challenge in the field, where traditional methods have focused heavily on screening rather than progression. Their 2025 paper on B-SPA has already garnered 9 citations, demonstrating immediate impact. Additionally, their 2023 work on low-cost robotics for high-throughput crystallography (4 citations) showcases their commitment to making advanced techniques accessible. Hassell-Hart's research promises to unlock the full potential of fragment-based approaches, accelerating the discovery of new therapeutics. Their innovative integration of synthesis, purification, and structural biology represents a paradigm shift in how researchers can efficiently transform initial fragment hits into potent drug candidates.
Research Focus
Key Achievements
Top Papers
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