Oleg Fedorov
Papers
3
Total Citations
14
H-Index
3
About
Oleg Fedorov is a structural biologist and chemical biologist whose work bridges the frontiers of fragment-based drug discovery and high-throughput crystallography. His research focuses on developing innovative methodologies to accelerate the progression of fragment hits into potent lead compounds—a historically challenging bottleneck in early-stage drug development. Fedorov’s major contributions include pioneering the B-SPA (Binding-Site Purification of Actives) technique, which combines multi-step array synthesis with high-throughput crystallography to efficiently deconvolute crude reaction mixtures and map binding sites. His 2023 and 2024 papers (4 and 3 citations, respectively) demonstrate how low-cost robotics and structural data can transform fragment screening into a rapid, scalable progression pipeline. Notably, Fedorov also contributed to astrophysics instrumentation, co-authoring the first ground-based detection of the CATS-LIDAR on the ISS using the TAIGA-HiSCORE facility (2017, 7 citations), showcasing his versatility. With a growing citation footprint and a focus on democratizing structural biology through accessible automation, Fedorov’s work is reshaping how researchers approach fragment hit optimization, making him a key figure in the next generation of drug discovery technology.
Research Focus
Key Achievements
Top Papers
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