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Joel L. Sussman is a structural biologist whose research has made significant contributions to structural genomics, proteomics, and the development of tools that accelerate three-dimensional protein structure determination. Working prominently through the Israel Structural Proteomics Center (ISPC), Sussman has championed the systematic determination of protein structures in their functional context — particularly proteins complexed with partner proteins or DNA relevant to human health. This emphasis on biological relevance distinguishes his center's approach within the broader structural genomics community. Sussman has also advanced the technical infrastructure of modern structural biology. His team developed HalX, an open-source Laboratory Information Management System (LIMS) designed to help small and large laboratories manage the data demands of high-throughput structure determination, garnering 28 citations as a practical resource for the field. Further methodological contributions include work on high-throughput pH optimization of protein crystallization, addressing key bottlenecks in obtaining diffraction-quality crystals. His structural studies, such as the crystal structure of YagE from *Escherichia coli K12*, illuminate proteins with potential implications for understanding drug resistance and pathogenicity. Collectively, Sussman's work bridges computational infrastructure, crystallographic methodology, and biomedically relevant structural biology.