Nicolas Leulliot
Papers
2
Total Citations
43
H-Index
2
About
Nicolas Leulliot is a structural biologist whose work has been instrumental in advancing high-throughput structural genomics, particularly through the development of open-source tools and optimized experimental pipelines. His research focuses on the systematic determination of protein structures using X-ray crystallography and NMR, aiming to build a universal protein-fold dictionary. Leulliot’s major contributions include the creation of *HalX*, an open-source Laboratory Information Management System (LIMS) designed to streamline data management for small- to large-scale laboratories. This tool, cited 28 times, has helped structural biology labs keep pace with the explosive growth of protein sequence data. He also played a key role in the South Paris Yeast Structural Genomics Project, where he developed high-throughput crystal-optimization strategies to overcome the crystallization bottleneck—a challenge that once stymied large-scale structure determination. His work on automated nanodrop crystallization screens, cited 15 times, demonstrated that "one size fits all" approaches could be refined for greater efficiency. Leulliot’s contributions have made structural genomics more accessible and scalable, enabling faster protein structure elucidation and advancing our understanding of the proteome.
Research Focus
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Top Papers
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