L. Tresaugues
Papers
2
Total Citations
43
H-Index
2
About
L. Tresaugues is a structural biologist whose work has been instrumental in advancing high-throughput structural genomics, particularly through the development of open-source laboratory information management systems (LIMS) and automated crystallization strategies. Their most cited paper, "HalX: an open-source LIMS for small- to large-scale laboratories" (2005, 28 citations), addresses a critical bottleneck in structural genomics: managing the explosive growth of protein sequence data. By providing a freely available, scalable platform for tracking samples and experimental data, Tresaugues enabled laboratories of all sizes to participate in systematic structure determination via X-ray crystallography and NMR. This contribution has been foundational for collaborative, large-scale projects aiming to build a universal protein-fold dictionary. In a second highly cited work (2005, 15 citations), Tresaugues tackled another major hurdle: protein crystallization. Their study on "High-throughput crystal-optimization strategies in the South Paris Yeast Structural Genomics Project" demonstrated that automated nanodrop crystallization screens could be effectively standardized, moving the bottleneck from setup to optimization. This work helped establish "one size fits all" approaches that are now common in structural biology pipelines. Through these contributions, Tresaugues has significantly improved the efficiency and accessibility of structural genomics, impacting fields from drug discovery to fundamental molecular biology.
Research Focus
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Top Papers
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