Orly Dym
Papers
3
Total Citations
19
H-Index
3
About
Orly Dym is a structural biologist whose research sits at the intersection of protein crystallography, structural proteomics, and human health. Based at the Israel Structural Proteomics Center (ISPC), Dym has been instrumental in advancing the determination of three-dimensional protein structures within their functional biological contexts — a technically demanding approach that prioritizes capturing proteins in complex with natural binding partners and DNA, rather than in isolation. This work, cited ten times, reflects a broader commitment to producing biologically meaningful structural data with direct relevance to human disease. Dym has also contributed to bacterial structural biology, including resolving the crystal structure of YagE, a DHDPS-like protein from *Escherichia coli K12*, shedding light on proteins potentially linked to bacteriophage-mediated drug resistance and pathogenicity. Her methodological contributions extend to the practical challenges of protein crystallization, with work on high-throughput pH optimization helping streamline workflows critical to structural proteomics pipelines worldwide. Though operating in a highly specialized field, Dym's research collectively advances the technical and scientific foundations that enable structure-based drug discovery and our understanding of protein function at the molecular level.
Research Focus
Key Achievements
Top Papers
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- 3High Throughput pH Optimization of Protein Crystallization4 citations · 2008