Papers
1
Total Citations
8
H-Index
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About
Hye Rim Hwang is a molecular biologist whose research centers on drug target identification and the mechanisms of bioactive compounds, particularly within fission yeast models. Her most notable contribution is the pioneering application of genome-wide drug-induced haploinsufficient screening in fission yeast to uncover the cellular targets of hydrazinocurcumin (HC), a synthetic curcumin derivative with known anti-angiogenic properties. This work, published in 2008 and cited 8 times, provided critical insights into the molecular pathways underlying HC’s effects, addressing a key gap in understanding how this compound inhibits angiogenesis. By leveraging the power of haploinsufficiency profiling, Hwang’s study offered a systematic approach to drug target discovery, advancing the development of improved curcumin-based therapeutics with enhanced pharmacological profiles. Her research exemplifies the integration of chemical biology and yeast genetics to elucidate drug mechanisms, laying groundwork for future studies in anticancer and anti-angiogenic drug development. Hwang’s work remains a valuable reference for researchers exploring natural product derivatives and functional genomic screening methodologies.
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