Papers
1
Total Citations
8
H-Index
1
About
Kwang-Lae Hoe is a prominent researcher in functional genomics and chemical biology, with a focus on elucidating drug mechanisms using model organisms. His major contributions center on the development and application of genome-wide screening techniques, particularly in fission yeast, to identify molecular targets of bioactive compounds. His notable work includes a 2008 study on hydrazinocurcumin (HC), a synthetic curcumin derivative with anti-angiogenic properties, where he employed a genome-wide drug-induced haploinsufficient screening approach to uncover HC's cellular targets. This work, cited 8 times, exemplifies his innovative strategy for connecting drug action to genetic pathways, advancing the understanding of how natural product derivatives exert their effects. Hoe's research has significant implications for drug discovery and development, providing a platform for identifying improved pharmacological compounds. His achievements highlight his expertise in integrating genomics, cell biology, and pharmacology to decode complex drug mechanisms, making him a key figure in the field of chemical genetics and target identification.
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