Papers
1
Total Citations
8
H-Index
1
About
Dong Uk Kim is a molecular geneticist whose research centers on chemical genomics, drug target identification, and the molecular mechanisms of bioactive compounds, with a particular emphasis on fission yeast as a model system. His major contributions include pioneering the use of genome-wide drug-induced haploinsufficient screening in Schizosaccharomyces pombe to uncover the cellular targets of novel therapeutics. In his highly cited 2008 study, Kim applied this approach to hydrazinocurcumin (HC), a synthetic curcumin derivative known to inhibit angiogenesis through unknown mechanisms. By systematically identifying genes whose heterozygous deletion conferred hypersensitivity to HC, he revealed the drug's molecular targets, providing critical insights into its anti-angiogenic activity. This work has had lasting impact, accumulating 8 citations and establishing a powerful methodology for elucidating the mode of action of poorly characterized compounds. Kim's research is instrumental for drug development, enabling the rational design of improved pharmacological agents with greater efficacy and specificity. His innovative use of yeast genetics continues to inform chemical biology and cancer research, making him a notable figure in the field of chemical genomics.
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