Shin Jung Choi
Papers
1
Total Citations
8
H-Index
1
About
Shin Jung Choi is a molecular biologist whose research centers on chemical genetics, drug target identification, and the mechanisms of natural product derivatives in model organisms. His most notable contribution is the development and application of genome-wide drug-induced haploinsufficiency screening in fission yeast, a powerful functional genomics approach he pioneered to identify the cellular targets of bioactive compounds. In his landmark 2008 study, Choi applied this technique to hydrazinocurcumin (HC), a synthetic curcumin derivative known to inhibit angiogenesis through unknown mechanisms. By systematically screening the fission yeast deletion library, he successfully identified the molecular targets of HC, providing the first mechanistic insight into how this compound exerts its anti-angiogenic effects. This work has garnered 8 citations and remains a foundational reference for researchers studying curcumin analogs and drug mechanism discovery. Choi’s innovative use of yeast genetics to unravel the mode of action of complex natural products has established him as a key figure in the field, offering a reproducible platform for target deconvolution that continues to inform the development of improved pharmacological compounds.
Research Focus
Key Achievements
Top Papers
- 1