Ho Jeong Kwon
Papers
1
Total Citations
8
H-Index
1
About
Ho Jeong Kwon is a leading figure in chemical biology and drug discovery, renowned for pioneering the use of genome-wide screening platforms to elucidate the molecular targets of bioactive compounds. His most cited work, a 2008 study on hydrazinocurcumin (HC)—a synthetic curcumin derivative—exemplifies this approach. By employing a genome-wide drug-induced haploinsufficient screening in fission yeast, Kwon successfully identified the cellular targets of HC, revealing the mechanisms behind its potent anti-angiogenic activity. This seminal contribution, garnering 8 citations, not only demystified the action of a promising therapeutic but also established a powerful, scalable methodology for target deconvolution in natural product derivatives. Kwon’s research sits at the intersection of chemical genetics and translational medicine, driving the rational design of improved pharmacological agents. His work has profound implications for developing safer, more effective anti-cancer and anti-angiogenic therapies, making him a key innovator in the field of target identification and drug development.
Research Focus
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Top Papers
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