Sangjo Han
Papers
1
Total Citations
8
H-Index
1
About
Sangjo Han is a molecular biologist whose research centers on chemical genetics, drug target identification, and the mechanisms of bioactive compounds, with a particular focus on fission yeast as a model system. His most cited work, a 2008 study on hydrazinocurcumin (HC), exemplifies his approach: using genome-wide drug-induced haploinsufficient screening in fission yeast to uncover the molecular targets of this synthetic curcumin derivative, which is known to inhibit angiogenesis through poorly understood pathways. This pioneering method allowed Han to systematically identify genes whose reduced dosage confers hypersensitivity to HC, directly linking the compound to specific cellular processes. With 8 citations, this paper has provided a foundational framework for understanding HC’s mechanism of action, aiding the development of improved anti-angiogenic compounds with better pharmacological properties. Han’s contributions are particularly notable for bridging chemical biology and functional genomics, demonstrating how yeast genetics can efficiently deconvolute drug mechanisms relevant to human disease. His work continues to influence researchers exploring natural product derivatives and targeted therapies, highlighting the power of model organisms in translational drug discovery.
Research Focus
Key Achievements
Top Papers
- 1