Cy M. Jeffries

Papers

Total Citations

611

H-Index

About

Cy M. Jeffries is a leading figure in structural biology, specializing in the development and application of biological small-angle X-ray scattering (SAXS). His major contributions center on advancing high-throughput, automated SAXS methodologies to unravel the structures of macromolecular complexes in solution. Jeffries played a pivotal role in designing and optimizing the P12 beamline at the PETRA III synchrotron (DESY), a facility that has become a global benchmark for biological solution scattering. His work on "Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline" has garnered over 600 citations, reflecting its transformative impact on the field. By introducing scatterless slits and automated sample handling, he enabled researchers to collect high-quality data with unprecedented efficiency and reduced artifacts. Jeffries’ innovations have empowered structural biologists to study dynamic biomolecular systems under near-physiological conditions, bridging gaps between crystallography and cryo-EM. His achievements underscore a career dedicated to pushing the boundaries of experimental biophysics, making him an indispensable resource for students and researchers seeking to explore the architecture of life at the nanoscale.