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U. Frommherz is a key figure in advancing macromolecular crystallography instrumentation, with a primary focus on the engineering and development of high-precision diffractometers. His major contribution is the design and implementation of the D3 diffractometer, a unified system created for the three macromolecular crystallography beamlines at the Swiss Light Source. This instrument represents a critical evolution in microcrystallography, building upon and extending previous high-resolution endstation developments for the undulator beamlines X06SA and X10SA. The D3 project, with components fabricated in-house at the Paul Scherrer Institute, showcases Frommherz’s expertise in bridging engineering challenges with the demanding requirements of synchrotron science. His most cited work, detailing the D3 diffractometer (2014, 23 citations), underscores the instrument’s impact on the community by enabling more precise and efficient data collection from microcrystals. Through this achievement, Frommherz has directly contributed to the structural biology capabilities at the Swiss Light Source, facilitating high-resolution studies of complex macromolecules.