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Goran Kotrle is a key figure in advancing macromolecular crystallography instrumentation, with his work centered on the design and implementation of cutting-edge diffractometers for synchrotron beamlines. His primary contributions lie in the engineering and development of the D3 diffractometer, a unified system created for the three macromolecular crystallography beamlines at the Swiss Light Source (SLS). This instrument critically extends previous designs to enable high-resolution microcrystallography, allowing researchers to study smaller and more challenging protein crystals. Kotrle’s most cited work, "D3, the new diffractometer..." (2014, 23 citations), details how this system was built upon earlier developments for the undulator beamlines X06SA and X10SA. A further publication (2013, 2 citations) provides in-depth engineering specifics, highlighting components fabricated in-house at the Paul Scherrer Institute. Through this achievement, Kotrle has directly enhanced the capabilities of structural biology research, enabling more precise data collection and supporting discoveries in drug design and molecular biology. His work exemplifies the critical role of instrumentation engineering in pushing the boundaries of X-ray science.