Papers
2
Total Citations
65
H-Index
2
About
Fabien Dobias is a key figure in advancing automation for macromolecular crystallography (MX), with his work directly shaping how synchrotron beamlines operate today. His primary research focuses on developing high-throughput robotic systems and innovative sample preparation techniques to streamline the notoriously labor-intensive steps of crystal mounting and cryoprotection. His most influential work, "RoboDiff" (2016, 44 citations), details the creation of a combined sample changer and goniometer that dramatically increased the speed, reliability, and capacity for automated mounting of cryocooled crystals—a technology now standard at most MX beamlines. Beyond automation, Dobias tackled the critical bottleneck of cryoprotectant-induced damage. In his 2014 study (21 citations), he prototyped a high-pressure cooling apparatus that enables the cooling of biological crystals without exogenous cryoprotectants, preserving crystal integrity by transforming the solvent into a high-density glass. This dual contribution—pioneering both robotic handling and cryoprotectant-free cooling—has made his work foundational for researchers seeking to maximize data collection efficiency and quality at synchrotron facilities worldwide.
Research Focus
Key Achievements
Top Papers
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