Jeroen Jacobs
Papers
2
Total Citations
30
H-Index
2
About
Jeroen Jacobs is a leading figure in the development of high-pressure macromolecular crystallography, a field that pushes the boundaries of structural biology by exploring how extreme conditions alter protein structure and function. His most significant contribution is the design of a high-throughput system for high-pressure cooling of biological crystals without cryoprotectants, a breakthrough that preserves native crystal structures and enables data collection at synchrotrons with unprecedented efficiency. This work, cited 21 times, addresses a critical bottleneck in crystallography by eliminating the need for potentially damaging additives. Jacobs also engineered a novel pneumatic diamond anvil cell, operable via a six-axis robotic arm, capable of generating continuous pressures up to 2.5 GPa and temperatures from 293 to 393 K. This device, cited 9 times, not only facilitates pressure and temperature annealing but also opens new avenues for studying protein dynamics under non-ambient conditions. His achievements are foundational for researchers aiming to capture transient states and pressure-induced conformational changes, making his work essential for advancing our understanding of protein stability and function in extreme environments.
Research Focus
Key Achievements
Top Papers
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