Sean Mc Sweeney
Papers
1
Total Citations
21
H-Index
1
About
Sean Mc Sweeney is a leading figure in macromolecular crystallography, whose work has fundamentally advanced the way biological crystals are prepared for structural analysis. His primary research focuses on developing innovative cryocooling techniques that eliminate the need for traditional cryoprotectants, which can often damage or alter delicate protein crystals. Mc Sweeney’s most notable contribution is the design and prototyping of a high-throughput, high-pressure cooling system, detailed in his 2014 paper (21 citations). This apparatus enables the vitrification of aqueous solvent within crystals by transforming it into a high-density, glass-like state, preserving their native structure for synchrotron-based X-ray diffraction. By solving the long-standing problem of cryoprotectant-induced artifacts, his work has opened new avenues for studying radiation-sensitive and difficult-to-crystallize macromolecules. Mc Sweeney’s achievements are pivotal for structural biologists seeking more accurate models of proteins, enzymes, and complexes, directly impacting drug discovery and our understanding of biological mechanisms at the atomic level.
Research Focus
Key Achievements
Top Papers
- 1