David Flot
Papers
2
Total Citations
82
H-Index
2
About
David Flot is a leading figure in macromolecular crystallography (MX), specializing in the development of advanced instrumentation and automation for synchrotron beamlines. His key research areas include robotic sample handling, high-throughput crystallography, and beamline optimization, with a focus on enabling efficient, reliable data collection for structural biology. Flot’s major contribution is the design and implementation of RoboDiff, a pioneering system that integrates a sample changer with a goniometer to fully automate the mounting and centering of cryocooled crystals. This innovation, detailed in his 2016 paper (44 citations), has significantly increased throughput and reproducibility at MX beamlines worldwide, reducing manual intervention and enabling remote experiments. His 2015 overview of the European Synchrotron Radiation Facility’s MX beamlines (38 citations) further underscores his impact, documenting the state-of-the-art infrastructure that supports thousands of researchers annually. Flot’s work has been instrumental in advancing structural biology, accelerating studies of proteins, viruses, and drug targets. His achievements include shaping the design of modern beamlines and fostering a culture of automation that has become a standard in the field, making him a key architect of today’s high-performance crystallography facilities.
Research Focus
Key Achievements
Top Papers
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