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Andreas Engel is a pioneering structural biologist whose research has fundamentally advanced the field of membrane protein crystallography and electron microscopy. His work centers on developing innovative high-throughput methodologies for studying membrane proteins — molecules of critical importance in cell physiology and prime targets for drug development. Engel's most significant contributions lie in creating sophisticated automated tools and workflows that dramatically streamline the notoriously challenging process of membrane protein 2D crystallization. His landmark development of the 2DX robot, a versatile "Swiss Army knife" for 2D crystallization, alongside automated electron microscopy screening systems, has transformed how researchers approach structural studies of these complex molecules. By connecting microfluidics to electron microscopy, Engel further expanded the technical repertoire available to structural biologists. His papers have collectively accumulated over 100 citations, reflecting the tangible impact his methodological innovations have had on the broader research community. His high-throughput tool-chains for sample preparation and microscopic analysis have been particularly valuable, addressing longstanding bottlenecks in membrane protein structure determination. Engel's legacy is one of elegant technical problem-solving, empowering researchers worldwide to unlock structural insights essential for understanding disease mechanisms and accelerating drug discovery.