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About

Mohamed Chami is a leading figure in structural biology and nanobiotechnology, whose work bridges the gap between membrane protein crystallography and synthetic biology. His major contributions center on the development of automated, high-throughput methods for electron microscopy, including the pioneering "2DX robot"—a versatile tool that revolutionized the preparation and screening of 2D crystallization trials for membrane proteins. This innovation, detailed in his 2009 and 2010 papers (37 and 36 citations, respectively), has significantly accelerated structural studies of challenging membrane proteins. More recently, Chami has ventured into the design of dynamic, out-of-equilibrium nanosystems. His highly cited 2022 work (117 citations) introduces photoswitchable polymersome nanoreactors that mimic circadian rhythms through light-gated chemical communication, enabling non-equilibrium enzymatic feedback loops. This breakthrough demonstrates his ability to merge structural biology with synthetic biology, creating artificial cellular machinery. With a career spanning from foundational EM automation to cutting-edge nanoreactor engineering, Chami’s research continues to inspire new approaches in both membrane protein structure determination and the construction of life-like, responsive nanomaterials.