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About

Yingssu Tsai is a structural biologist whose work has advanced the frontier of macromolecular crystallography, particularly in the realm of high-throughput data collection from radiation-sensitive samples. Her research focuses on developing innovative sample-delivery methods and grid technologies that enable efficient mounting and data acquisition from multiple small crystals—a critical capability for microfocus synchrotron beamlines and femtosecond X-ray free-electron laser experiments. Her most cited work, "High-density grids for efficient data collection from multiple crystals" (2015, 75 citations), introduced a transformative approach that dramatically increased throughput for challenging structural investigations, allowing researchers to maximize data from precious, radiation-sensitive crystals. This contribution has been instrumental in enabling productive femtosecond crystallography studies, where sample efficiency is paramount. Tsai's work sits at the intersection of instrumentation development and structural biology, providing essential tools that have accelerated the determination of structures from difficult targets. Her innovations have been widely adopted by the synchrotron community, making her a key figure in the ongoing evolution of crystallographic methods for next-generation beamlines.