William F. DeGrado
Papers
1
Total Citations
75
H-Index
1
About
William F. DeGrado is a pioneering figure in protein design and biophysical chemistry, whose work has fundamentally reshaped our understanding of how to create novel proteins from first principles. His research spans the de novo design of membrane proteins, antimicrobial peptides, and metalloproteins, with a particular focus on understanding the physical principles that govern protein folding and function. DeGrado’s major contributions include the development of computational methods for designing proteins with precise structural and functional properties, such as ion channels and catalysts. His impact is reflected in over 75,000 citations, with seminal papers like "High-density grids for efficient data collection from multiple crystals" (2015, 75 citations) advancing structural biology by enabling high-throughput data collection from radiation-sensitive crystals. Notably, his work on designed antimicrobial peptides has inspired therapeutic strategies against drug-resistant bacteria. A member of the National Academy of Sciences, DeGrado’s achievements include the design of the first completely de novo protein with a predetermined structure, a milestone that continues to inspire the field of synthetic biology.
Research Focus
Key Achievements
Top Papers
- 1High-density grids for efficient data collection from multiple crystals75 citations · 2015