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About

William C. Budell is a structural biologist at the forefront of methodological innovation in cryo-electron microscopy (cryo-EM). His primary research focus is the development of time-resolved cryo-EM techniques, specifically aimed at capturing short-lived molecular states that occur during dynamic biological processes. Budell’s major contribution is his work on Spotiton, a novel robotic system for preparing cryo-EM grids that enables rapid mixing and vitrification of samples. This technology allows researchers to “freeze” and visualize transient molecular interactions—such as those triggered by the early encounter of two or more particles—which have long been an experimental challenge in the field. His landmark 2020 paper, “Time-resolved cryo-EM using Spotiton,” has garnered 151 citations, underscoring its significance in advancing structural biology. Budell’s work bridges the gap between static structural snapshots and dynamic molecular movies, opening new avenues for studying fundamental biological processes and drug-target interactions. His achievements represent a critical step toward routine time-resolved structural studies, making him a key innovator in the cryo-EM community.