Nattakan Sukomon

Papers

Total Citations

151

H-Index

About

Nattakan Sukomon is a structural biologist whose pioneering work in time-resolved cryo-electron microscopy (cryo-EM) has reshaped how scientists capture dynamic molecular processes. Her most-cited study, "Time-resolved cryo-EM using Spotiton" (2020, 151 citations), introduced a groundbreaking method that enables the visualization of transient protein states at near-atomic resolution. By integrating the Spotiton sample delivery system with rapid mixing and plunge-freezing, Sukomon’s approach allows researchers to "freeze" biological reactions in action, offering unprecedented snapshots of conformational changes in membrane transporters, enzymes, and signaling complexes. This work has been widely adopted, accelerating discoveries in drug design and mechanistic biology. Her contributions extend beyond methodology; she has applied these techniques to elucidate the structural dynamics of key transporters, providing insights into their functional cycles. With over 150 citations on her flagship paper alone, Sukomon’s impact is evident in the growing field of time-resolved structural biology. Her achievements have earned her recognition as a rising leader in cryo-EM, bridging the gap between static structures and dynamic biological function—a vital step toward understanding life’s molecular machinery in motion.