Sine Larsen

Papers

Total Citations

111

H-Index

About

Sine Larsen is a leading figure in macromolecular crystallography, whose work has fundamentally shaped how structural biology experiments are conducted. Her primary research focuses on the development of automated sample handling and cryocrystallography techniques, enabling high-throughput data collection at synchrotron facilities. Larsen’s most influential contribution is her role in defining the SPINE standard sample holder for cryocooled macromolecular crystals, a specification detailed in her 2006 paper (cited 111 times). This standardized vial and mounting system, designed for robotic sample changers, has become a global benchmark, drastically reducing manual intervention and human error in crystallographic pipelines. Beyond this technical milestone, Larsen has made significant contributions to the structural study of proteins and nucleic acids, advancing our understanding of their function. Her work has been instrumental in making macromolecular crystallography more accessible and efficient, directly accelerating discoveries in drug design and molecular biology. For her pioneering efforts, she has been recognized as a leader in the field, with her innovations now standard practice in laboratories worldwide.