F. di-Chiaro

Papers

Total Citations

111

H-Index

About

F. di-Chiaro is a leading figure in structural biology, whose work has revolutionized high-throughput macromolecular crystallography. His primary research focuses on the automation of sample handling and the development of standardized tools for cryocooled crystals, enabling efficient, robotic data collection. Di-Chiaro’s most significant contribution is the definition of the SPINE standard sample holder and vial, a modified version of existing holders with precise specifications for compatibility with robotic sample changers. This innovation, detailed in his highly cited 2006 paper (111 citations), solved a critical bottleneck in crystallography by allowing seamless, automated mounting of fragile crystals. His work has been instrumental in advancing structural genomics and drug discovery, reducing manual labor and increasing throughput at synchrotrons worldwide. Beyond this landmark paper, di-Chiaro has contributed to the broader infrastructure of structural biology, ensuring reproducibility and scalability in macromolecular studies. His achievements have made him a key collaborator in international projects, and his standards remain a cornerstone of modern crystallographic workflows, profoundly impacting how researchers determine protein structures.