C. Taffut

Papers

Total Citations

111

H-Index

About

C. Taffut has made foundational contributions to structural biology, particularly in macromolecular crystallography, by advancing automation and standardization in sample handling. Their most-cited work, "Automation of sample mounting for macromolecular crystallography" (2006, 111 citations), introduced the SPINE standard sample holder—a modified, precisely specified cryocooled crystal vial and holder designed for robotic sample changers. This innovation streamlined high-throughput data collection, enabling more efficient protein structure determination. By defining a universal interface, Taffut’s work reduced manual handling errors and accelerated structural studies of biological macromolecules, directly impacting synchrotron beamline operations worldwide. Their contributions have been instrumental in automating crystallography workflows, supporting large-scale projects like structural genomics. With over 100 citations on this key paper alone, Taffut’s legacy lies in bridging engineering and biology, making cutting-edge structural analysis more accessible to researchers globally.