Papers
4
Total Citations
68
H-Index
4
About
Lin Shi is a pioneering neuroscientist whose research focuses on the neural circuitry of epilepsy, particularly the therapeutic mechanisms of deep brain stimulation (DBS) for temporal lobe epilepsy (TLE). Her major contributions center on elucidating how DBS of the anterior nuclei of the thalamus (ANT-DBS) modulates basal ganglia dysfunction and protects hippocampal neurons. In a landmark 2020 study (25 citations), Shi demonstrated that ANT-DBS relieves basal ganglia dysfunction in epileptic monkeys, providing critical insights into seizure propagation pathways. Her work further revealed that ANT-DBS activates autophagy—a cellular cleanup process—to protect hippocampal neurons, a finding with profound implications for neuroprotection in epilepsy (14 citations). Shi also developed innovative tools for epilepsy research, including a robotic-assisted lead implantation system for nonhuman primates (17 citations) and a novel mesial TLE monkey model using robot-assisted kainic acid injection (12 citations). Her translational approach bridges basic neuroscience and clinical application, offering new avenues for refining DBS therapies. With a growing citation impact, Shi’s research is shaping our understanding of how neuromodulation can treat drug-resistant epilepsy.
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