Jian‐Guo Zhang

Beijing Institute of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College

Papers

Total Citations

H-Index

About

Jian-Guo Zhang is a leading neuroscientist whose research bridges epilepsy therapeutics and spinal deformity correction. His most influential work explores deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) for temporal lobe epilepsy. In a landmark 2020 study, Zhang demonstrated that ANT-DBS protects hippocampal neurons by activating autophagy in epileptic monkeys, offering a mechanistic explanation for the therapy’s neuroprotective effects. This work, with 14 citations, has opened new avenues for understanding how electrical stimulation can modulate cellular waste-clearing pathways to prevent seizure-induced brain damage. Beyond epilepsy, Zhang has made significant contributions to congenital scoliosis research. His 2025 comprehensive review synthesizes advances in the genetic and environmental origins of vertebral malformations, providing clinicians with an up-to-date framework for diagnosis and treatment. By integrating molecular mechanisms with clinical applications, Zhang’s research has advanced both fundamental neuroscience and surgical practice. His work exemplifies how translational research can bridge bench discoveries—like autophagy activation—to bedside therapies, making him a key figure in neuromodulation and pediatric orthopedics.