Larisa Avramova
Purdue University West Lafayette, State Street (United States)
Papers
6
Total Citations
161
H-Index
6
About
Larisa Avramova is a pioneering researcher at the intersection of high-throughput experimentation, automation, and chemical synthesis, with particular expertise in mass spectrometry-based analytical platforms and flow chemistry. Her work has fundamentally advanced how chemists discover and optimize reaction conditions, replacing laborious traditional methods with rapid, automated screening systems capable of evaluating thousands of reactions in a fraction of the time. Avramova's most influential contribution — her 2020 implementation of desorption electrospray ionization mass spectrometry (DESI-MS) for high-throughput screening, garnering 52 citations — demonstrated how microdroplet chemistry and robotics could be seamlessly integrated to accelerate reaction discovery. Complementing this, her high-throughput studies on nucleophilic aromatic substitution and Suzuki–Miyaura cross-coupling reactions, with 37 and 35 citations respectively, validated these platforms across industrially critical reaction classes and bridged screening with continuous flow manufacturing. Her earlier work in single-cell drug screening and robotic combinatorial library synthesis reveals a consistent career-long dedication to automation-driven science across both pharmaceutical and synthetic chemistry domains. More recently, her application of HTE to biorenewable platform molecules highlights a growing commitment to sustainable chemistry. Collectively, her research empowers both academic and industrial scientists to make faster, data-rich decisions in chemical development.
Research Focus
Key Achievements
Top Papers
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- 4High-Throughput Secondary Screening at the Single-Cell Level15 citations · 2013
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