David H. Thompson
Purdue University West Lafayette, State Street (United States)
Papers
5
Total Citations
176
H-Index
5
About
David H. Thompson is a prominent chemist whose research sits at the intersection of high-throughput experimentation, automated synthesis, and continuous flow chemistry. His work has fundamentally advanced how organic reactions are discovered and optimized, replacing traditionally slow, labor-intensive screening processes with rapid, automated workflows capable of evaluating thousands of reactions per day. Thompson's most significant contributions center on coupling liquid handling robotics with desorption electrospray ionization mass spectrometry (DESI-MS) to create powerful high-throughput screening platforms. His systems have been applied across a range of reaction classes, including reductive amination, nucleophilic aromatic substitution, and Suzuki–Miyaura cross-coupling reactions — demonstrating the broad versatility of his approach. His 2020 work on hardware and software implementation of DESI-MS screening has garnered 52 citations, reflecting its methodological influence on the field. Beyond synthetic optimization, Thompson has extended his platform to sustainable chemistry, exploring aldol reactions of the biorenewable molecule triacetic acid lactone as part of a broader interest in green chemistry applications. By consistently bridging high-throughput discovery with continuous flow validation, Thompson has established a rigorous and scalable paradigm for modern reaction development that continues to shape pharmaceutical and chemical research practice.
Research Focus
Key Achievements
Top Papers
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