Cheryl Holdman

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About

Cheryl Holdman is a researcher specializing in high-throughput screening (HTS) technologies, with a focus on automating and accelerating drug discovery and microbial analysis at unprecedented scales. Her work bridges instrumentation engineering, analytical chemistry, and biomedical research to develop innovative platforms that streamline complex screening processes. Holdman's most notable contribution is her development of an automated single-cell-multiple functional response system for drug screening, published in 2013 and cited 15 times. This system integrates semiautomated sample preparation, high-speed collection, and real-time analytical tools capable of processing 384-well compound dilutions, significantly reducing the time and resources required in early-stage drug discovery pipelines. Her 2012 work, cited 12 times, introduced a microbial HTS instrument leveraging elastic light scatter (ELS) patterns to enable high-speed combinatorial studies directly on bacterial colonies. By combining forward scatterometry with robotic incubation and automated plate transport, she created a powerful tool for antimicrobial research and microbial characterization. Together, these contributions demonstrate Holdman's commitment to pushing the boundaries of screening technology, providing researchers with faster, more precise tools for both pharmaceutical and microbiological applications. Her work is particularly valuable to scientists seeking scalable, cost-effective solutions in drug development and infectious disease research.