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About

Hans Clevers is a pioneering stem cell biologist whose work has fundamentally reshaped our understanding of tissue regeneration and disease modeling. His primary research focuses on adult stem cells, organoid technology, and the molecular mechanisms of the Wnt signaling pathway. Clevers is best known for his groundbreaking discovery that Lgr5 marks actively dividing stem cells in the intestine and other tissues, a finding that led directly to his development of the first "mini-organs" or organoids—self-organizing 3D structures grown from single stem cells. This revolutionary platform, now used globally, allows researchers to model diseases like cancer and cystic fibrosis, test drugs, and explore personalized medicine. His highly cited work includes contributions to the FANTOM5 project (361 citations), which mapped transcription initiation across the human genome, and studies on liver organoids grafted onto microfluidic vascular beds (108 citations). With over 100,000 total citations and numerous awards, including the prestigious Breakthrough Prize, Clevers continues to drive innovation in regenerative medicine, offering unprecedented tools for studying human biology outside the body.