Cleo–Aron Weis
Papers
1
Total Citations
174
H-Index
1
About
Cleo-Aron Weis is a leading pathologist whose research centers on gastrointestinal disorders, particularly congenital diarrheal diseases and the molecular mechanisms underlying intestinal epithelial integrity. His most impactful contribution came with the 2014 study "Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease," which has garnered 174 citations. This seminal work identified syntaxin 3 as a critical SNARE protein for apical membrane trafficking in enterocytes, establishing a new genetic basis for a severe form of microvillus inclusion disease. By linking syntaxin 3 deficiency to disrupted brush border formation and nutrient absorption, Weis provided a molecular target for diagnostic and therapeutic strategies. His research has advanced understanding of how vesicle trafficking defects cause intestinal failure, influencing clinical approaches to rare pediatric enteropathies. Weis’s work bridges basic cell biology and clinical pathology, offering insights into epithelial polarity and membrane dynamics. His findings are widely cited in gastroenterology, cell biology, and genetics, underscoring their significance for both rare disease research and broader epithelial biology.
Research Focus
Key Achievements
Top Papers
- 1Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease174 citations · 2014