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About

Dr. Sachi Ishikawa-Kato is a leading computational biologist whose work has fundamentally advanced our understanding of gene regulation through the precise mapping of transcription initiation. Her primary research focuses on transcriptomics, functional genomics, and the development of high-resolution sequencing methodologies. Dr. Ishikawa-Kato is best known for her pivotal contributions to the international FANTOM5 consortium, where she co-authored the landmark 2017 study "FANTOM5 CAGE profiles of human and mouse samples." This highly influential work, which has garnered over 360 citations, established a comprehensive atlas of transcription start sites across nearly three thousand human and mouse samples at single base-pair resolution. By applying Cap Analysis of Gene Expression (CAGE) coupled with single-molecule sequencing, her research enabled the systematic monitoring of promoter and enhancer activity on an unprecedented scale. This foundational resource has become an essential reference for researchers studying gene regulation, cellular identity, and disease mechanisms, cementing Dr. Ishikawa-Kato’s reputation as a key architect of modern regulatory genomics.