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Dr. Hiroshi Kawamoto is a leading figure in functional genomics, best known for his pivotal role in the FANTOM5 consortium. His research centers on the regulation of gene expression, particularly through the precise mapping of transcription initiation events across the mammalian genome. Kawamoto’s most significant contribution is his landmark 2017 paper, "FANTOM5 CAGE profiles of human and mouse samples," which has garnered over 360 citations. In this work, he and his team utilized Cap Analysis of Gene Expression (CAGE) coupled with single-molecule sequencing to map transcription start sites at single base-pair resolution across approximately three thousand human and mouse samples. This monumental effort created an unparalleled atlas of promoters and enhancers, fundamentally advancing our understanding of transcriptional regulation in health and disease. By providing a high-resolution, quantitative view of the transcriptome, Kawamoto’s work has become an essential resource for researchers studying gene networks, cellular identity, and the molecular basis of complex traits.