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About

Haruhiko Koseki is a leading figure in mammalian epigenetics and gene regulation, best known for his pioneering work on Polycomb group (PcG) proteins and their role in developmental gene silencing. His research has fundamentally shaped our understanding of how chromatin modifications control cell identity, stem cell pluripotency, and lineage commitment. Koseki’s major contributions include elucidating the molecular mechanisms by which PcG complexes mediate histone modifications, particularly H3K27me3, and demonstrating their essential functions in embryonic development and hematopoiesis. His work has had a profound impact, with key papers accumulating thousands of citations. Notably, he was a central contributor to the FANTOM5 consortium, which produced the landmark 2017 study on CAGE-based transcription initiation maps across human and mouse samples (361 citations), providing an unprecedented resource for understanding gene regulatory networks. Koseki’s achievements include receiving the Japanese Society for Epigenetics Award and serving as a team leader at RIKEN, where his lab continues to drive discoveries in the epigenetic control of development and disease.